Low dose radiosensitivity of alloimmune cytotoxic T cells.

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Low dose radiosensitivity of alloimmune cytotoxic T cells

Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains...

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The effects of ionizing radiation on the immune system relate primarily to the radiosensitivity of the small lymphocyte. Within the past several years, as our concepts of cell-cell interactions have evolved with emphasis on functional subsets of lymphocytes, it has become clear that subpopulations differ in their radiosensitivity (1). Further, the lymphocyte is unique, in that radiation-induced...

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CD28-independent costimulation of T cells in alloimmune responses.

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Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis

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Impact of dose-rate on the low-dose hyper-radiosensitivity and induced radioresistance (HRS/IRR) response.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1982

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.155.6.1858